Bidirectional Communication of Estrogen in Gut-Brain Axis: Evidencefrom Preclinical and Clinical Studies

Targeting GM modulation presents a promising therapeutic strategy for mitigating GBA dysfunction in postmenopausal women. This review consolidates existing evidence and highlights the need for further research into microbiota-based interventions to alleviate estrogen deficiency- related neurophysiological disorders.

Authors

Sheenam Sharma (ORCID: https://orcid.org/0009-0002-1693-7634)
Kanwaljit Chopra (ORCID: https://orcid.org/0000-0001-5898-6093)
Sumeet Gupta (ORCID: https://orcid.org/0000-0003-2980-7791)
Nitin Bansal
Rishabh Chaudhary
Seema Bansal

Institutions

Chaudhary Devi Lal University (IN)
Maharishi Markandeshwar University, Mullana (IN)
Panjab University (IN)

Publication Details

Journal: Current Drug Targets
Published: 2026-01-15
DOI: https://doi.org/10.2174/0113894501406082251019170714
Primary Topic: Menopause: Health Impacts and Treatments
Type: article
Field-Weighted Citation Impact: 0.00

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article

Bidirectional Communication of Estrogen in Gut-Brain Axis: Evidencefrom Preclinical and Clinical Studies

Sheenam Sharma, Kanwaljit Chopra, Sumeet Gupta, Nitin Bansal et al.

Jan 15, 2026

Current Drug Targets

Menopause: Health Impacts and Treatments

article

Bidirectional Communication of Estrogen in Gut-Brain Axis: Evidencefrom Preclinical and Clinical Studies

Sheenam Sharma, Kanwaljit Chopra, Sumeet Gupta, Nitin Bansal, Rishabh Chaudhary, Seema Bansal

January 15, 2026article en

Abstract

Targeting GM modulation presents a promising therapeutic strategy for mitigating GBA dysfunction in postmenopausal women. This review consolidates existing evidence and highlights the need for further research into microbiota-based interventions to alleviate estrogen deficiency- related neurophysiological disorders.

Current Drug TargetsVol. 27

Chaudhary Devi Lal University (IN), Maharishi Markandeshwar University, Mullana (IN), Panjab University (IN)

Gender equality

Openalex Percentile: Top 79%

Menopause: Health Impacts and Treatments

DOI Source OpenAlex

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