Lower airway immunophenotyping in severe preschool wheeze reveals distinct clusters described by heterogeneity in neutrophil phenotypes
Airway inflammation in RSW is heterogeneous. A sub-group have airway neutrophilia, but with distinct neutrophil subtypes. Those with bacterial infection had CD62Llo neutrophils (Cluster 1). Others had CD62Lhi neutrophils (Clusters 2 & 3). Intervention trials stratifying using these clusters may provide a novel management approach.
Authors
- Mindy Gore (ORCID: https://orcid.org/0000-0002-1458-1438)
- Kushalinii Hillson (ORCID: https://orcid.org/0000-0002-2675-288X)
- Kunyuan Tian (ORCID: https://orcid.org/0000-0001-5163-6381)
- Elizabeth Scotney (ORCID: https://orcid.org/0000-0002-9264-4174)
- Adnan Čustović
- James M. Cook (ORCID: https://orcid.org/0000-0001-8447-6126)
- Haya Al-Kuwari
- Mohamed H. Shamji (ORCID: https://orcid.org/0000-0003-3425-3463)
- Ashley Hoffland (ORCID: https://orcid.org/0000-0003-2051-9363)
- Clare M. Lloyd (ORCID: https://orcid.org/0000-0001-8977-6726)
- Janice A. Layhadi (ORCID: https://orcid.org/0000-0002-5242-1806)
- Katie Bonner
- Andrew Bush
- Sara Fontanella
- Sejal Saglani
- Breathing Together Investigators
Institutions
- The Francis Crick Institute (GB)
- Royal Brompton Hospital (GB)
- Lung Institute (US)
- Institute of Child Health (IN)
- Imperial College London (GB)
- Royal College of Paediatrics and Child Health (GB)
Publication Details
- Journal
- American Journal of Respiratory and Critical Care Medicine
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1093/ajrccm/aamaf119
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 32.84