WHEN SKIN TURNS AGAINST THE BODY: A CLOSER LOOK AT SJS AND TEN

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis are very rare, severe, life-threatening dermatological conditions characterized by severe skin and mucosal changes. The most common triggers are drugs, including β-lactam antibiotics, allopurinol, nonsteroidal anti-inflammatory drugs, nevirapine, and febuxostat. This article reviews the literature from 2000-2025 on the clinical manifestations that characterize SJS/TEN, pathogenesis, diagnosis necessary for proper treatment, prognostic scales such as SCORTEN, ABCD-10 and CRISTEN useful for predicting patient mortality, and treatment. Due to the rarity and high mortality rate of people with SJS/TEN, there is still a lack of high-quality studies on the pathogenesis of the disease and evaluating the efficacy of immunomodulatory drugs in inhibiting epidermal necrolysis and reducing mortality.