Spatial Transcriptomics Uncovers Hybrid, Pro-Inflammatory and Pro-Fibrotic Cellular Niches in Pulmonary Granuloma of Patients with Chronic Sarcoidosis
Taken together, macrophages in the center of the sarcoidosis granuloma form an armed-and-ready, hybrid pro-inflammatory and pro-fibrotic niche, supporting granuloma persistence through continuous IFN-γ stimulation and collagen expression by fibroblasts localized in periphery of granuloma.
Authors
- Jonas C. Schupp (ORCID: https://orcid.org/0000-0002-7714-8076)
- L Neubert
- Christine S. Falk (ORCID: https://orcid.org/0000-0003-1376-7318)
- Theresa Graalmann (ORCID: https://orcid.org/0000-0003-1856-0981)
- Ivana V. Yang (ORCID: https://orcid.org/0000-0002-1018-489X)
- Mark Greer (ORCID: https://orcid.org/0000-0003-3234-306X)
- Raphael Ewen (ORCID: https://orcid.org/0000-0002-5623-9788)
- Semih Bayraktar (ORCID: https://orcid.org/0000-0001-9549-7117)
- Danny Jonigk (ORCID: https://orcid.org/0000-0002-5251-2281)
- Jan Fuge (ORCID: https://orcid.org/0000-0003-2926-3608)
- Naftali Kaminski (ORCID: https://orcid.org/0000-0001-5917-4601)
- Antje Prasse
- Jannik Ruwisch (ORCID: https://orcid.org/0000-0003-1654-6668)
- Shu-Yi Liao
- Hande Yilmaz
- Leonard Christian
- Leon Giercke
- Fabio Ius
- Yang Li
- Jan C Kamp
- Jens Gottlieb
- Benjamin Seeliger
- Jens M Hohlfeld
Institutions
- Radboud University Nijmegen (NL)
- Colorado School of Public Health (US)
- University of Basel (CH)
- University Hospital of Basel (CH)
- Radboud University Medical Center (NL)
- National Jewish Health (US)
- Yale University (US)
- Medizinische Hochschule Hannover (DE)
- Hospital Base (CL)
- Radboud Institute for Molecular Life Sciences (NL)
- Fraunhofer Institute for Toxicology and Experimental Medicine (DE)
- German Center for Lung Research (DE)
- Center for Vascular Biology Research (US)
- Centre for Individualised Infection Medicine (DE)
- Center for Experimental and Clinical Infection Research (DE)
- Artificial Intelligence in Medicine (Canada) (CA)
- University of Colorado Anschutz Medical Campus (US)
- RWTH Aachen University (DE)
- University of Colorado Denver (US)
Publication Details
- Journal
- American Journal of Respiratory and Critical Care Medicine
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1093/ajrccm/aamaf089
- Primary Topic
- Sarcoidosis and Beryllium Toxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00