A trans-omics gene-smoking interaction study of lung cancer based on consortium data
The xWAS framework enables systematic discovery of trans-omics gene-environment interactions. The MMS effectively delineates the patterns of the interaction effects and facilitates risk stratification. Additionally, we launched a free online platform, LungCancer-xWAS-GxE (http://bigdata.njmu.edu.cn/LungCancer-xWAS-GxE/).
Authors
- Xiaoping Xu (ORCID: https://orcid.org/0000-0002-8934-1287)
- H. Shen
- Jiacheng Zhou (ORCID: https://orcid.org/0000-0003-1092-3848)
- Ning Xie (ORCID: https://orcid.org/0000-0002-0116-1426)
- Anpeng Wang (ORCID: https://orcid.org/0000-0002-9165-6085)
- Yanru Wang (ORCID: https://orcid.org/0000-0001-8272-2450)
- Ming Zhao (ORCID: https://orcid.org/0000-0003-2000-2241)
- Manel Esteller
- David C Christiani
- Yang Zhao
- Yongyue Wei
- Christopher I Amos
- Feng Chen
- Yi Li
- Ruyang Zhang
- Zhibin Hu
- Xuan Wang
- Xiang Wang
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Harvard University (US)
- Baylor College of Medicine (US)
- Peking University (CN)
- Lunenfeld-Tanenbaum Research Institute (CA)
- University of Michigan (US)
- Massachusetts General Hospital (US)
- Josep Carreras Leukaemia Research Institute (ES)
- Ministry of Education (RO)
- Office of Readiness and Response (US)
- Department of Physiological Sciences (RU)
- Jiangsu Provincial Center for Disease Control and Prevention (CN)
- Houston Institute for Clinical Research (US)
- Jiangsu Cancer Hospital (CN)
- Changzhou No.2 People's Hospital (CN)
- Changzhou University (CN)
- Changzhou Third People's Hospital (CN)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Nanjing Medical University (CN)
Publication Details
- Journal
- American Journal of Respiratory and Critical Care Medicine
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1093/ajrccm/aamaf097
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00