The Relationship between Helicobacter pylori Infection and Dyslipidemia in Hypertension: Case-Control Model

Abstract Background: Hypertension and/or Helicobacter pylori infections have an increasing prevalence in populations. H. pylori normally colonizes the stomach due to its ability to resist high acidity. Under abnormal conditions, it can cause infection through various virulence factors. Objective: The current study aims to determine the relationship between H. pylori IgG prevalence and lipid profile in hypertension using a case-control model. Materials and Methods: A total of 68 cases (34 hypertension and 34 healthy) were attended to at Al-Hakeem General Hospital in AL-Najaf Province, Iraq, during the period from July 2022 to September 2022, with an age range of 35–65 years. The blood specimens were aspirated and tested for H. pylori IgG using a rapid test (Lungene, China) and for lipid profiles using RX Daytona Analyzer (Randox, United Kingdom), following the instructions of manufacturing companies. Results: The mean age was significantly higher in hypertension than in control ( P = 0.033), with the predominant age group in hypertension patients being 56–65 years. This study revealed that H. pylori was insignificantly higher in hypertension than in control group ( P = 0.089). The lipid profile (cholesterol, triglycerides, and low-density lipoprotein) in hypertension patients was significantly P = 0.000, P = 0.000, and P = 0.000) higher in both the presence and absence of anti- H. pylori IgG ( P = 0.000) than in control group, respectively. However, high-density lipoprotein level was insignificantly different between patients and controls in both presence ( P = 0.394) and absence ( P = 0.133) of anti- H. pylori IgG. Conclusion: Lipid profile abnormalities are related to hypertension, without difference in the presence and absence of anti- H. pylori IgG by case-control model.