THE ROLE OF DIGITAL THERAPEUTICS IN THE MANAGEMENT OF MYOFASCIAL PAIN SYNDROME: A COMPREHENSIVE REVIEW

Background: Myofascial Pain Syndrome (MPS) is a prevalent musculoskeletal condition involving trigger points, chronic pain, and functional limitations. Digital therapeutics (DTx) have gained attention as accessible tools that support rehabilitation and self-management in chronic pain. Purpose of Research: This review aimed to synthesize current evidence on the clinical usefulness of digital interventions—such as telehealth, mobile applications, virtual reality, and wearable sensors—in the management of MPS and related myofascial pain. Materials and Methods: A systematic review was performed according to PRISMA 2020. Searches across major databases identified studies evaluating digital therapeutics for MPS or chronic musculoskeletal pain with myofascial components. Eligible study designs included randomized trials, quasi-experimental studies, cohort studies, and systematic reviews. Two reviewers independently conducted screening, data extraction, risk-of-bias assessment (RoB2, ROBINS-I, AMSTAR 2), and evaluation of evidence certainty using GRADE. Results: Digital interventions generally reduced pain, improved function, and supported adherence to therapeutic exercises. Telehealth physiotherapy and app-based rehabilitation showed effectiveness comparable to traditional in-person care. Virtual reality contributed to greater engagement and reductions in pain-related fear, while wearable sensors enhanced monitoring and promoted consistent home-based activity. Together, these tools improved self-management and complemented standard physiotherapy approaches. Conclusion: Digital therapeutics provide a valuable adjunct in managing Myofascial Pain Syndrome, offering flexible, personalized, and patient-centered care. Although current evidence is promising, more high-quality MPS-specific randomized trials are needed to refine clinical guidance.