Phase 2b trial of inhaled imatinib for treatment of pulmonary arterial hypertension

Add-on dry powder inhaled imatinib (AV-101) was not effective in lowering PVR at any of the studied doses in patients with PAH. The phase 3 part of the IMPAHCT study was halted.

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Publication Details

Journal
American Journal of Respiratory and Critical Care Medicine
Published
2026-01-05
DOI
https://doi.org/10.1093/ajrccm/aamaf128
Primary Topic
Pulmonary Hypertension Research and Treatments
Type
article
Field-Weighted Citation Impact
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article

Phase 2b trial of inhaled imatinib for treatment of pulmonary arterial hypertension

BEN DAKE, Naomi Habib, Grzegorz Kopeć, ALICIA RAMIREZ et al.
American Journal of Respiratory and Critical Care Medicine
Pulmonary Hypertension Research and Treatments
article

Phase 2b trial of inhaled imatinib for treatment of pulmonary arterial hypertension

BEN DAKE, Naomi Habib, Grzegorz Kopeć, ALICIA RAMIREZ, Sanjeev Khindri, Hunter Gillies, Pilar Escribano-subias, Stefano Ghio, V Mclaughlin, Ralph W. Niven, Xiaosha Zhang, Jonathan Langley, N.S. Hill, Mardi I. Gomberg-Maitland, David Langleben, Franz P. Rischard, Zhi-Cheng Jing, Murali M Chakinala, Olivier Sitbon, Marius M Hoeper, Stephan Rosenkranz, Jeremy P Feldman, Adrian Lescano, IMPAHCT Investigators, Marc Humbert
article en

Abstract

Add-on dry powder inhaled imatinib (AV-101) was not effective in lowering PVR at any of the studied doses in patients with PAH. The phase 3 part of the IMPAHCT study was halted.

American Journal of Respiratory and Critical Care Medicine
Jagiellonian University (PL), Tufts Medical Center (US), Memorial Hospital of South Bend (US), University of Arizona (US), Inserm (FR), University of Cologne (DE), George Washington University (US), Washington University in St. Louis (US), Université Paris-Saclay (FR), Jewish General Hospital (CA), Foundation Center (US), Medizinische Hochschule Hannover (DE), Pauls Stradiņš Clinical University Hospital (LV), Hospital Universitario 12 De Octubre (ES), John Paul II Hospital (PL), Michigan Medicine (US), Fundacion Favaloro Hospital Universitario (AR), Arizona Pain Specialists (US), Banner - University Medical Center Tucson (US), Riga Stradiņš University (LV), German Center for Lung Research (DE), NKT Therapeutics (United States) (US), Guangdong Academy of Medical Sciences (CN), Policlinico San Matteo Fondazione (IT), University Hospital Cologne (DE), Favaloro Foundation (AR), Bicêtre Hospital (FR), University of Monterrey (MX)
Openalex Percentile: Top 80%
Pulmonary Hypertension Research and Treatments
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