Phase 2b trial of inhaled imatinib for treatment of pulmonary arterial hypertension
Add-on dry powder inhaled imatinib (AV-101) was not effective in lowering PVR at any of the studied doses in patients with PAH. The phase 3 part of the IMPAHCT study was halted.
Authors
- BEN DAKE
- Naomi Habib (ORCID: https://orcid.org/0009-0006-3388-0616)
- Grzegorz Kopeć (ORCID: https://orcid.org/0000-0001-9921-2801)
- ALICIA RAMIREZ
- Sanjeev Khindri
- Hunter Gillies (ORCID: https://orcid.org/0009-0003-6677-7445)
- Pilar Escribano-subias
- Stefano Ghio (ORCID: https://orcid.org/0000-0002-1858-1152)
- V Mclaughlin
- Ralph W. Niven
- Xiaosha Zhang
- Jonathan Langley
- N.S. Hill
- Mardi I. Gomberg-Maitland
- David Langleben
- Franz P. Rischard
- Zhi-Cheng Jing
- Murali M Chakinala
- Olivier Sitbon
- Marius M Hoeper
- Stephan Rosenkranz
- Jeremy P Feldman
- Adrian Lescano
- IMPAHCT Investigators
- Marc Humbert
Institutions
- Jagiellonian University (PL)
- Tufts Medical Center (US)
- Memorial Hospital of South Bend (US)
- University of Arizona (US)
- Inserm (FR)
- University of Cologne (DE)
- George Washington University (US)
- Washington University in St. Louis (US)
- Université Paris-Saclay (FR)
- Jewish General Hospital (CA)
- Foundation Center (US)
- Medizinische Hochschule Hannover (DE)
- Pauls Stradiņš Clinical University Hospital (LV)
- Hospital Universitario 12 De Octubre (ES)
- John Paul II Hospital (PL)
- Michigan Medicine (US)
- Fundacion Favaloro Hospital Universitario (AR)
- Arizona Pain Specialists (US)
- Banner - University Medical Center Tucson (US)
- Riga Stradiņš University (LV)
- German Center for Lung Research (DE)
- NKT Therapeutics (United States) (US)
- Guangdong Academy of Medical Sciences (CN)
- Policlinico San Matteo Fondazione (IT)
- University Hospital Cologne (DE)
- Favaloro Foundation (AR)
- Bicêtre Hospital (FR)
- University of Monterrey (MX)
Publication Details
- Journal
- American Journal of Respiratory and Critical Care Medicine
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1093/ajrccm/aamaf128
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00