Substance use disorders exhibit unique and disorder specific genetic associations with externalizing and internalizing psychopathology
From these findings we conclude that shared genetic influences may explain comorbidity observed between SUDs and internalizing disorders and suggest that genetic risk for internalizing should be incorporated into SUD identification and prevention efforts. Future gene identification efforts should study SUDs in the context of both externalizing and internalizing psychopathology.
Authors
- Denise Hien (ORCID: https://orcid.org/0000-0002-7073-6924)
- Danielle Dick
- Maia Choi
- Holly Poore
- Peter B. Barr
- David Zald
Institutions
- Rutgers, The State University of New Jersey (US)
- SUNY Downstate Health Sciences University (US)
- VA NY Harbor Healthcare System (US)
- Johnson University (US)
- Rutgers Sexual and Reproductive Health and Rights (NL)
- Environmental and Occupational Health Sciences Institute (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-22
- DOI
- https://doi.org/10.64898/2026.01.19.26344398
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00