MA-T Activates Human TRPV4 in the Non-pigmented Ciliary Epithelial Cells
Matching transformation system (MA-T), an on-demand aqueous chlorine dioxide production solution is utilized in various applications, including antibacterial and cancer therapies. Herein, we focused on the ability of MA-T in oxidizing human transient receptor potential cation channel subfamily V member 4 (hTRPV4), which functions as a redox sensor, using Ca<sup>2+</sup> imaging and patch-clamp experiments. We found that 10 ppm MA-T activated hTRPV4 in HEK293T cells. Moreover, MA-T induced increase in cytosolic calcium concentration through hTRPV4 activation in human non-pigmented ciliary epithelial cells. Our study findings suggest MA-T as a potential agent for TRPV4-related diseases.
Authors
- Qianwen Luo (ORCID: https://orcid.org/0009-0002-5488-633X)
- Miho Hashimoto
- Makoto TOMINAGA
- F. Fujita
- M. Toriyama
- Tsuyoshi Inoue
Institutions
- Japan Society for the Promotion of Science (JP)
- Nagoya City University (JP)
- Towa Pharmaceutical (Japan) (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Biological and Pharmaceutical Bulletin
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1248/bpb.b25-00537
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00