Study Integrating GWAS and pQTL Data Identifies Potential Therapeutic Targets for Hypertension

This proteome-wide MR analysis demonstrates a causal relationship between genetically determined levels of ACE, AGT, and NPPA and hypertension. These proteins represent promising targets for the development of novel hypertension therapeutics.

Authors

Yiduo Wang (ORCID: https://orcid.org/0000-0002-8787-0134)
Huan Qu (ORCID: https://orcid.org/0000-0001-9152-9011)

Institutions

Zhongda Hospital Southeast University (CN)

Publication Details

Journal: Current Computer - Aided Drug Design
Published: 2026-01-12
DOI: https://doi.org/10.2174/0115734099382081251126112854
Primary Topic: Genetic Associations and Epidemiology
Type: article
Field-Weighted Citation Impact: 0.00

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article

Study Integrating GWAS and pQTL Data Identifies Potential Therapeutic Targets for Hypertension

Yiduo Wang, Huan Qu

Jan 12, 2026

Current Computer - Aided Drug Design

Genetic Associations and Epidemiology

article

Study Integrating GWAS and pQTL Data Identifies Potential Therapeutic Targets for Hypertension

Yiduo Wang, Huan Qu

January 12, 2026article en

Abstract

Current Computer - Aided Drug DesignVol. 22

Zhongda Hospital Southeast University (CN)

Good health and well-being

Openalex Percentile: Top 74%

Genetic Associations and Epidemiology

DOI Source OpenAlex

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Study Integrating GWAS and pQTL Data Identifies Potential Therapeutic Targets for Hypertension — Yiduo Wang, Huan Qu · Current Computer - Aided Drug Design (2026) | TGRS Research Map | TGRS