Development and Validation of a LASSO-Logistic Regression Model for Predicting Disseminated Intravascular Coagulation in Pediatric Hemophagocytic Lymphohistiocytosis
The LASSO-logistic prediction model, incorporating three readily available biomarkers, demonstrated promising discriminative ability for predicting DIC risk in pediatric HLH. This tool may facilitate early risk stratification and timely therapeutic interventions to improve clinical outcomes.
Authors
- Haipeng Yan
- Xun Li (ORCID: https://orcid.org/0009-0005-6744-994X)
- Longlong Xie (ORCID: https://orcid.org/0000-0002-5690-9083)
- Zhang Ben-shan
- Xun Li (ORCID: https://orcid.org/0000-0002-1173-1066)
- Jiaan Gan
- Jiaotian Huang
- Ting Luo
- Haiyan Luo
- Xiangyu Wang
- Xinping Zhang
Institutions
- Central South University (CN)
- Hunan Children's Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- Shock
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1097/shk.0000000000002776
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00