Senescence-induced endothelial-to-mesenchymal transition accelerates the subretinal fibrosis in neovascualr age-related macular degeneration
The accumulation of senescent endothelial cells promotes subretinal fibrosis via EndMT in nAMD. Targeting these cells represents a promising therapeutic strategy for mitigating fibrosis-associated vision loss.
Authors
- Yinhao Wang
- Hongguang Cui (ORCID: https://orcid.org/0000-0001-9770-6621)
- Huiling Ma
- Kuangqi Chen (ORCID: https://orcid.org/0000-0002-2444-3987)
- Kai Chen (ORCID: https://orcid.org/0000-0002-0560-8061)
- Jianqin Shen
- Xinlei Pan
- Tiantian Cheng
- Jianhua Xia
- Jiayun Ge
- Xinglin Wang
- Yan Sheng
- Hui Ye
Institutions
- Chinese University of Hong Kong (HK)
- Peking University (CN)
- Peking University First Hospital (CN)
- Shandong Eye Hospital (CN)
- Shandong First Medical University (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1186/s12967-026-07707-z
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00