CF3-Substituted Benzothiazepines as Promising Anticancer Agents

Objective: To synthesize and characterize a new series of CF3-substituted benzothiazepines and evaluate their anticancer activity. Methods: The compounds 5a–5n were synthesized and characterized using FT-IR, NMR spectroscopy, and elemental analysis. Their anticancer activity was evaluated against A549, MCF-7, and HepG2 cell lines using the SRB assay. Results and Discussion: The compounds demonstrated moderate to good activity against all tested cell lines. Notably, compound 5j showed significant activity against all three cell lines. Conclusions: These findings highlight the potential of this series for the development of novel anticancer agents.