Integrative transcriptomic profiling links telomere dysfunction to cGAS–STING activation in heart failure signatures in mice and humans
These findings establish telomere dysfunction as a pathogenic driver that engages innate immune signaling via the cGAS -STING pathway, with direct relevance to human heart failure.
Authors
- Sana’a Khraisat
- Qi Luo
- Helen M. Blau (ORCID: https://orcid.org/0000-0001-6503-5480)
- Moritz Brandt (ORCID: https://orcid.org/0000-0001-7686-7485)
- Philip Wenzel
- Megan Mayerle
- P Lurz
- Phil Tsao
- Uwe Raaz
- Thomas Münzel
Institutions
- Johannes Gutenberg University Mainz (DE)
- VA Palo Alto Health Care System (US)
- Cardiovascular Institute of the South (US)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- German Centre for Cardiovascular Research (DE)
- University of Göttingen (DE)
- Stanford University (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1093/cvr/cvag013
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 24.43