Regulation of HSF-1 by FBXW7 to Alleviate Multidrug Resistance in Ovarian Cancer
FBXW7 acts as a tumour suppressor that mitigates MDR in ovarian cancer by negatively regulating the HSF-1/P-gp pathway. The findings have offered mechanistic insights into chemoresistance and highlight the therapeutic potential of targeting FBXW7-HSF-1 signaling in EOC management.
Authors
- Xiaoni Zhou
- Fujun Liu
- Fen Yang
- Yiran Xiao
- Gang null Hu
- Kaiyi Li
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Current Cancer Drug Targets
- Published
- 2026-01-12
- DOI
- https://doi.org/10.2174/0115680096427366251126115802
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00