Spontaneous cervical artery dissection is associated with a distinct peripheral immune cell signature
CeAD is associated with a distinct peripheral immune signature characterized by enhanced cytotoxic activity and reduced regulatory features. These alterations may reflect a post-infectious autoimmune mechanism triggering CeAD or a secondary immune-inflammatory response to vascular injury. Larger, longitudinal studies are needed to clarify causality and assess whether immune modulation could serve as a therapeutic target in CeAD.
Authors
- Timo Wirth (ORCID: https://orcid.org/0000-0002-0102-4608)
- Christian Thomas (ORCID: https://orcid.org/0000-0002-6642-7774)
- Daniel Strunk (ORCID: https://orcid.org/0000-0002-1314-1561)
- Andreas Schulte‐Mecklenbeck (ORCID: https://orcid.org/0000-0003-3855-4706)
- Ilka Kleffner (ORCID: https://orcid.org/0000-0003-3207-9684)
- Carolin Beuker
- Luisa Klotz
- Catharina C. Gross
Institutions
- Philipps University of Marburg (DE)
- University of Münster (DE)
- Universitätsklinikum Knappschaftskrankenhaus Bochum (DE)
- University Hospital Schleswig-Holstein (DE)
- Technical University of Applied Sciences Lübeck (DE)
- Ruhr University Bochum (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1371/journal.pone.0340592
- Primary Topic
- Intracranial Aneurysms: Treatment and Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft