Organic N-Nitro Reagents in Organic Synthesis

Abstract Organic N-nitro reagents are emerging as efficient nitrating agents in modern organic chemistry. Traditionally, nitration methodologies rely on the use of mixed acids employing harsh reaction conditions. The use of N-nitro compounds offers milder, greener, and more sustainable alternatives. These organic reagents facilitate the introduction of nitro groups into a variety of aromatic and aliphatic substrates with improved regio- and chemoselectivity, as well as excellent functional group tolerance. Their growing utility in pharmaceutical and materials synthesis highlights their significance as valuable tools for sustainable nitration processes. In this review, we have described the organic transformation involving N-nitro reagents.