Resistance to second-generation integrase inhibitors in people with HIV following treatment failure on dolutegravir- or bictegravir-based ART in Taiwan

Although RAMs to second-generation INSTIs may be detected during treatment failure, the overall prevalence remains low for both dolutegravir- and bictegravir-based ART. Viral resuppression can be achieved through salvage therapy or continued use of second-generation INSTI-based regimens.

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Publication Details

Journal
Journal of Antimicrobial Chemotherapy
Published
2025-12-17
DOI
https://doi.org/10.1093/jac/dkaf488
Primary Topic
HIV/AIDS drug development and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Resistance to second-generation integrase inhibitors in people with HIV following treatment failure on dolutegravir- or bictegravir-based ART in Taiwan

Li-Shin Su, Nan-Yao Lee, Lin Cl, Yen‐Hsu Chen et al.
Journal of Antimicrobial Chemotherapy
HIV/AIDS drug development and treatment
article

Resistance to second-generation integrase inhibitors in people with HIV following treatment failure on dolutegravir- or bictegravir-based ART in Taiwan

Li-Shin Su, Nan-Yao Lee, Lin Cl, Yen‐Hsu Chen, Guan-Jhou Chen, Shih-Ping Lin, Miao-Hui Huang, Chien-Ching Hung, Mao-Sung Tsai, Sui-Yuan Chang, Sung-Hsi Huang, Bo-Huang Liou
article en

Abstract

Although RAMs to second-generation INSTIs may be detected during treatment failure, the overall prevalence remains low for both dolutegravir- and bictegravir-based ART. Viral resuppression can be achieved through salvage therapy or continued use of second-generation INSTI-based regimens.

Journal of Antimicrobial ChemotherapyVol. 81(2)
National Taiwan University (TW), Min Sheng General Hospital (TW), Tzu Chi Foundation (TW), Mackay Memorial Hospital (TW), Taichung Veterans General Hospital (TW), Far Eastern Memorial Hospital (TW), Chia-Yi Christian Hospital (TW), National Taiwan University Hospital (TW), Buddhist Tzu Chi Medical Foundation (US), National Cheng Kung University Hospital (TW), National Yunlin University of Science and Technology (TW)
Good health and well-being
Openalex Percentile: Top 28%
HIV/AIDS drug development and treatment
DOISourceOpenAlex
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Resistance to second-generation integrase inhibitors in people with HIV following treatment failure on dolutegravir- or bictegravir-based ART in Taiwan — Li-Shin Su, Nan-Yao Lee, et al. · Journal of Antimicrobial Chemotherapy (2025) | TGRS Research Map | TGRS