Network Pharmacology-Based Prediction of the Mechanistic Targets of CHKG in Treating Postpartum Hemorrhage
This study provides a systems-level prediction of the mechanisms by which CHKG may exert therapeutic effects in PPH, particularly via inflammation- and coagulationrelated pathways. These findings generate mechanistic hypotheses; however, further in vitro or in vivo experimental validation is required to confirm bioactivity and clinical relevance.
Authors
- Zhipeng Chen (ORCID: https://orcid.org/0000-0002-7546-6740)
- Yanxia Yu (ORCID: https://orcid.org/0009-0000-9752-2806)
- Chenqi Zhu
- Y Gu
- Tiantian Xiang
- Yijie Qian
- Jia Liu
- Tong Zhu
- Shangyang Lin
- Xiaowei Fan
- Xiaoxiao Ke
Institutions
- Nanjing University of Chinese Medicine (CN)
- Suzhou Municipal Hospital (CN)
- Xi’an Jiaotong-Liverpool University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2026-01-12
- DOI
- https://doi.org/10.2174/0113862073422452251121102657
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00