Neonatal Differences in Sexual Differentiation

Key Points Differences in sexual differentiation (DSD) defines a wide spectrum of conditions in which the development of chromosomal, gonadal, or anatomical sex is atypical.An infant born with atypical genitalia can cause a crisis for a family and requires sensitive, collaborative, and lifelong care.Sex assignment may not be possible immediately after delivery.DSD is subdivided into 46,XX DSD, 46,XY DSD, and sex chromosome DSD.Identifying the precise diagnosis is difficult and clinical management can be controversial; therefore, individualized, patient-centered, multidisciplinary care is paramount.