Single-cell transcriptomics uncovers malignant potential of gallbladder adenomyomatosis and identifies PRDX1+ immunosuppressive macrophages in gallbladder carcinoma
Our study reveals that GBA harbors malignant potential at both epithelial and immune microenvironmental levels. The expression of CCL20, CCL5, and PRDX1 may serve as molecular markers for stratifying high-risk GBA, while PRDX1 represents a promising therapeutic target for reprogramming the tumor immune microenvironment in GBC.
Authors
- Jiarong Li (ORCID: https://orcid.org/0000-0002-8763-8968)
- Yi Liu (ORCID: https://orcid.org/0000-0002-6592-9262)
- Junwei Fan (ORCID: https://orcid.org/0000-0002-2135-8728)
- Xiangsong Wu
- Jinxin Sheng
- Shijie Hu
- Yan Xia
- Xiaoqing Zhang
- Hong Li
- Song Zhu
- Liyun Yuan
Institutions
- University of Shanghai for Science and Technology (CN)
- Shanghai Jiao Tong University (CN)
- Nantong University (CN)
- XinHua Hospital (CN)
- Shanghai Chest Hospital (CN)
- SAIC-GM (China) (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Tongren Hospital (CN)
- International Peace Maternity & Child Health Hospital (CN)
- Second People's Hospital of NanTong (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1097/js9.0000000000004916
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00