Hydrogen Sulfide as a Mediator of Protein Persulfidation and Motility Regulation in Mammalian Sperm
This study provides the first comprehensive evidence that persulfidation is a functionally relevant modification in boar spermatozoa. H<sub>2</sub>S appears to modulate motility during capacitation, either through persulfidation of proteins or via ion channels and other signaling pathways. These findings highlight H<sub>2</sub>S signaling as a novel regulatory axis in male reproduction and suggest new avenues for fertility research. <i>Antioxid. Redox Signal.</i> 44, 572-598.
Authors
- Daniela Spevakova
- Ondřej Šimoník (ORCID: https://orcid.org/0000-0002-6577-765X)
- Natálie Zelenková
- Aneta Pilsova
- Zuzana Pilsova
- Marketa Sedmikova
- Pavla Postlerova
- Katerina Komrskova
- Barbora Klusackova
- Jessica Stekrova
Institutions
- Czech University of Life Sciences Prague (CZ)
- Charles University (CZ)
- Czech Academy of Sciences, Institute of Biotechnology (CZ)
Publication Details
- Journal
- Antioxidants and Redox Signaling
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1177/15230864251410465
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00