Nuciferine Prevents Obesity by Inhibiting Macrophage Inflammation InvolvingLGALS3, CTSB, and RBP4 Genes Based on an Integrative Analysis of AdiposeTissue Transcriptomics and Network Pharmacology
These findings suggest that nuciferine may reduce adipose tissue inflammation by inhibiting mRNA levels of macrophage inflammation-associated genes LGALS3, CTSB, and RBP4, thereby protecting against obesity and associated metabolic inflammation.
Authors
- Ruizhen Hou
- Hanyuan Xu
- Hua Yang (ORCID: https://orcid.org/0000-0001-7811-1657)
- Fengying Gong
- Wenjing Hu
- Yuxing zhao
- Yuchen Jiang
- Linjie Wang (ORCID: https://orcid.org/0000-0003-3227-9184)
- Hui Pan
- Xiaonan Guo
- Huijuan Zhu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2026-01-14
- DOI
- https://doi.org/10.2174/0113816128400528251121074807
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00