Geniposide Attenuates Post-Myocardial Infarction Cardiac Remodeling via Parkin-Dependent Suppression of Hyperactivated Mitophagy
GP alleviates post-MI remodeling by suppressing Parkin-dependent hyperactivated mitophagy, reducing cardiomyocyte loss and fibrosis. Parkin is central to GP's therapeutic effects, highlighting its potential as a target for MI-related heart failure. This study elucidates GP's cardioprotective mechanism and proposes Parkin pathway modulation as a novel strategy to counteract pathological cardiac remodeling.
Authors
- Yan Jiang (ORCID: https://orcid.org/0000-0001-6153-1997)
- Dan Li (ORCID: https://orcid.org/0000-0002-7314-0552)
- Qian Zhou (ORCID: https://orcid.org/0000-0001-7964-8130)
- Wei Yang
- Yao Su
- Honghong He
- Guanglei Chang
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Dazu District People's Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2026-01-13
- DOI
- https://doi.org/10.2174/0109298673402330251125051751
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00