Integrating Network Pharmacology with In Vitro Experiments Reveals Ferroptosis as a Key Mechanism Underlying Shikonin's AnticancerActivity in HCC

Together, shikonin exerts significant antitumor effects on HepG2 cells, and the underlying mechanism may involve targeting AURKA to induce ferroptosis.

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Publication Details

Journal
Combinatorial Chemistry & High Throughput Screening
Published
2026-01-12
DOI
https://doi.org/10.2174/0113862073414517251122065708
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Integrating Network Pharmacology with In Vitro Experiments Reveals Ferroptosis as a Key Mechanism Underlying Shikonin's AnticancerActivity in HCC

Ruijun Shi, S. Li, Nan Zhang, Yong Li et al.
Combinatorial Chemistry & High Throughput Screening
Ferroptosis and cancer prognosis
article

Integrating Network Pharmacology with In Vitro Experiments Reveals Ferroptosis as a Key Mechanism Underlying Shikonin's AnticancerActivity in HCC

Ruijun Shi, S. Li, Nan Zhang, Yong Li, Qilong Wu, Wenjing Zhang
article en

Abstract

Together, shikonin exerts significant antitumor effects on HepG2 cells, and the underlying mechanism may involve targeting AURKA to induce ferroptosis.

Combinatorial Chemistry & High Throughput ScreeningVol. 29
Tarim University (CN), Shanxi Fenyang Hospital (CN)
Openalex Percentile: Top 80%
Ferroptosis and cancer prognosis
DOIOpen Access PDFOpenAlex
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