Estrogen Exposure is Associated With Reduced Otosclerosis Risk in Obesity and Hormone Therapy
Obesity and estradiol HRT are associated with a decreased risk of developing otosclerosis. A similar but nonsignificant trend was found in patients with T2DM. This suggests a protective role of estrogen against otosclerosis. Future studies may serve to elucidate longitudinal hormone profiling and identify a therapeutic local intervention for individuals with otosclerosis.
Authors
- Delaney E S Clark
- Sudhanvan Iyer (ORCID: https://orcid.org/0009-0003-0744-9441)
- Brian J. McKinnon
- Maia Smith
- Simon Warren
Institutions
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- Otology & Neurotology Open
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1097/ono.0000000000000083
- Primary Topic
- Ear Surgery and Otitis Media
- Type
- article
- Field-Weighted Citation Impact
- 0.00