Causal Impact of Genetically Predicted Leptin Levels on Atrial Fibrillation Risk: Evidence from Bidirectional Mendelian Randomization Analysis
This study provides genetic evidence supporting a unidirectional causal effect of elevated leptin levels on AF risk, independent of adiposity. While these findings highlight leptin as a potential biomarker for AF susceptibility, further mechanistic and translational research is warranted to explore its role in atrial remodeling and therapeutic targeting.
Authors
- Fuyuan Li (ORCID: https://orcid.org/0000-0002-2981-234X)
- Yun Zhang
- Xianjun Wu
- Xiaoyong Huang
Institutions
- Wenzhou Medical University (CN)
- Lishui University (CN)
- Lishui City People's Hospital (CN)
Publication Details
- Journal
- Endocrine Metabolic & Immune Disorders - Drug Targets
- Published
- 2026-01-12
- DOI
- https://doi.org/10.2174/0118715303417995251113184235
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00