Humanized MISTRG6 Mice: A Relevant Translational Model for Examining Early Bone Marrow Changes in Acute CLP Sepsis
Humanized MISTRG6 mice reveal early bone marrow remodeling in CLP sepsis, including altered HSPC dynamics and niche composition. This model is highly translational for studying human hematopoiesis and therapeutic interventions after CLP.
Authors
- Tomasz Skirecki (ORCID: https://orcid.org/0000-0001-6233-7758)
- Grażyna Hoser (ORCID: https://orcid.org/0000-0002-0917-5611)
- Magdalena Ambrożek-Latecka (ORCID: https://orcid.org/0000-0003-1025-6280)
- Magdalena Bandyszewska (ORCID: https://orcid.org/0000-0002-1773-6116)
- Marcin F. Osuchowski (ORCID: https://orcid.org/0000-0002-1321-9883)
- Kosinska-Kaczynska Katarzyna
- Kacper Bielak
Institutions
- Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA (AT)
- Postgraduate School of Molecular Medicine (PL)
- Ludwig Boltzmann Institute for Digital Health and Prevention (AT)
Publication Details
- Journal
- Shock
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1097/shk.0000000000002660
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00