Investigation of the Antiepileptic and Anti-inflammatory Effects ofEmpagliflozin on Penicillin-induced Epileptiform Activity in Rats

Empagliflozin demonstrated anticonvulsant and anti-inflammatory effects by delaying seizure onset, reducing SWF, and modulating pro-inflammatory cytokine levels. These findings suggest that empagliflozin may have therapeutic potential in epilepsy through SGLT-2 inhibition.

Authors

Mehmet Kayhan (ORCID: https://orcid.org/0000-0001-7493-5165)
Merve Uzuner
Ayhan Cetinkaya

Institutions

Bolu Abant İzzet Baysal University (TR)

Publication Details

Journal: CNS & Neurological Disorders - Drug Targets
Published: 2026-01-14
DOI: https://doi.org/10.2174/0118715273423680251125073602
Primary Topic: Oral and gingival health research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Investigation of the Antiepileptic and Anti-inflammatory Effects ofEmpagliflozin on Penicillin-induced Epileptiform Activity in Rats

Mehmet Kayhan, Merve Uzuner, Ayhan Cetinkaya

Jan 14, 2026

CNS & Neurological Disorders - Drug Targets

Oral and gingival health research

article

Investigation of the Antiepileptic and Anti-inflammatory Effects ofEmpagliflozin on Penicillin-induced Epileptiform Activity in Rats

Mehmet Kayhan, Merve Uzuner, Ayhan Cetinkaya

January 14, 2026article en

Abstract

CNS & Neurological Disorders - Drug TargetsVol. 25

Bolu Abant İzzet Baysal University (TR)

Good health and well-being

Openalex Percentile: Top 80%

Oral and gingival health research

DOI Source OpenAlex

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Investigation of the Antiepileptic and Anti-inflammatory Effects ofEmpagliflozin on Penicillin-induced Epileptiform Activity in Rats — Mehmet Kayhan, Merve Uzuner, et al. · CNS & Neurological Disorders - Drug Targets (2026) | TGRS Research Map | TGRS