Sevoflurane-induced hemispheric cerebral blood flow reduction in mice with revived global perfusion after carotid artery occlusion
In this rUCCAO model, the principal hemodynamic deficit is a selective impairment in vasodilation, unmasked by sevoflurane, rather than sustained hypoperfusion. This identifies compromised cerebrovascular reactivity as a key pathophysiological alteration post-carotid occlusion.
Authors
- Juchen Li (ORCID: https://orcid.org/0000-0002-2883-7203)
- Rui Hao (ORCID: https://orcid.org/0000-0003-0031-8185)
- Fang Fang (ORCID: https://orcid.org/0000-0002-4023-2928)
- Jing Cang
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Jinshan Hospital of Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1186/s40001-025-03778-8
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Sciences