Enhancing Local Anesthetic Efficacy: Controlled Release of Ropivacaineusing Poly(lactic-co-glycolic) Acid-Polyvinyl Alcohol Nanocarriers

The PLGA-PVA-RPV nanocarriers demonstrate enhanced efficacy and biocompatibility for prolonged ropivacaine release offering a promising strategy for postoperative pain management. Future work should focus on in vivo validation and parameter optimization to facilitate clinical translation Conclusion: PLGA-PVA-RPV nanocarriers possess optimal physicochemical properties (small size, homogeneity, stability) and superior biosafety, providing a promising strategy for extending RPV's analgesic efficacy. This technology has significant potential to improve postoperative pain management.