Electrochemical Synthesis of 3-Selenyl-Chromones via Domino C(sp2)-H Bond Selenylation/Annulation of Enaminones
Herein, we disclose a highly efficient pathway toward 3-selenylated chromone derivatives via electrosynthesis domino C(sp<sup>2</sup>)-H bond selenylation/cyclization/deamination of 2-hydroxyaryl enaminones with diselenides. This method showed mild conditions, easy operation, a wide substrate scope, and good functional group tolerance. Furthermore, this electrosynthesis strategy was amenable to scaling up the reaction. Additionally, the preliminary experiments revealed that this reaction probably proceeded via a cation pathway instead of a radical pathway.
Authors
- Gleison Antônio Casagrande (ORCID: https://orcid.org/0000-0002-1667-913X)
- Alex Schneider
- Sumbal Saba (ORCID: https://orcid.org/0000-0002-6134-7249)
- André L. Stein (ORCID: https://orcid.org/0000-0001-7827-5790)
- Vijay P. Singh (ORCID: https://orcid.org/0000-0002-5584-2067)
- Giancarlo Viccari Botteselle
- Giuseppe A. Câmara (ORCID: https://orcid.org/0000-0002-6223-0130)
- João M. Brito
- Tiago E. A. Frizon (ORCID: https://orcid.org/0000-0001-5078-3478)
- Isabella M. e Oliveira
- Jamal Rafique
- Antonio L. Braga
- Cassio A. O. Moraes
Institutions
- Universidade Federal de Mato Grosso do Sul (BR)
- Universidade Federal de Mato Grosso (BR)
- Universidade Federal de Santa Catarina (BR)
- Universidade Estadual do Centro-Oeste (BR)
- Panjab University (IN)
- Universidade Federal de Goiás (BR)
Publication Details
- Journal
- Molecules
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3390/molecules31020391
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Federal de Goiás
- Universidade Federal de Mato Grosso do Sul