NSUN6 deficiency drives immune suppression in pancreatic cancer via the KDM5A-CCL2-macrophage axis
NSUN6 deficiency drives immune suppression through the m<sup>5</sup>C-KDM5A-CCL2 axis in PDAC. Targeting the NSUN6-CCL2 axis represents a promising strategy to sensitise PDAC to ICB therapy.
Authors
- Shaoqiu Liu (ORCID: https://orcid.org/0009-0002-5149-6045)
- Zilan Xu
- S. Liu
- Hongzhe Zhao (ORCID: https://orcid.org/0009-0005-9859-0452)
- Ji Liu (ORCID: https://orcid.org/0000-0002-9679-3716)
- Lingxing Zeng (ORCID: https://orcid.org/0000-0002-0846-8762)
- Y. Zhou
- Ziming Chen (ORCID: https://orcid.org/0000-0001-5987-0148)
- Ruihong Bai (ORCID: https://orcid.org/0009-0001-0050-9152)
- D. Wang
- Xiaoyu Wu
- Jialiang Zhang (ORCID: https://orcid.org/0000-0003-1626-6674)
- Shaojia Wu
- Sihan Zhao
- Xinyi Peng
- Chunling Xue
- Xudong Huang
- Qi Zhou
- Mei Li
- Jiachun Su
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Gut
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1136/gutjnl-2025-336541
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00