Characterization using ultra-deep sequencing of the intra-host distribution of the mutations associated with H. pylori antibiotic resistance

This first study using in-house high-throughput sequencing of H. pylori on clinical biopsies from the same patients reinforces the hypothesis that the bacterial population within the same host is heterogeneous. The presence of minority variants justifies the need for at least two biopsies to ensure robust testing of the H. pylori antibiotic susceptibility profile.

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Publication Details

Journal
Annals of Clinical Microbiology and Antimicrobials
Published
2026-01-22
DOI
https://doi.org/10.1186/s12941-025-00840-5
Primary Topic
Helicobacter pylori-related gastroenterology studies
Type
article
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article

Characterization using ultra-deep sequencing of the intra-host distribution of the mutations associated with H. pylori antibiotic resistance

Birama Ndiaye, Alexandra Hervé, Médéric Briand, Laura Chaufour et al.
Annals of Clinical Microbiology and Antimicrobials
Helicobacter pylori-related gastroenterology studies
article

Characterization using ultra-deep sequencing of the intra-host distribution of the mutations associated with H. pylori antibiotic resistance

Birama Ndiaye, Alexandra Hervé, Médéric Briand, Laura Chaufour, Maxime Pichon, Frédérique Lartigue, Christophe Burucoa
article en

Abstract

This first study using in-house high-throughput sequencing of H. pylori on clinical biopsies from the same patients reinforces the hypothesis that the bacterial population within the same host is heterogeneous. The presence of minority variants justifies the need for at least two biopsies to ensure robust testing of the H. pylori antibiotic susceptibility profile.

Annals of Clinical Microbiology and AntimicrobialsVol. 25(1)
Université de Tours (FR), Inserm (FR), Université de Poitiers (FR), Institut de Virologie (FR), Centre Hospitalier Universitaire de Tours (FR), Centre Hospitalier Universitaire de Poitiers (FR), Infectiologie et santé publique (FR)
Openalex Percentile: Top 80%
Helicobacter pylori-related gastroenterology studies
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