LINC00476 cooperates with ARIH2 and suppresses pancreatic cancer progression by inducing VIM ubiquitination
Our data suggest that LINC00476 enhances VIM ubiquitination and degradation by recruiting ARIH2, highlighting the role of LINC00476 in PDAC progression and indicating that the overexpression of LINC00476 or ARIH2 may serve as a promising therapeutic strategy for PDAC.
Authors
- Jinwei Cui (ORCID: https://orcid.org/0009-0001-6697-3046)
- H. W. Wang
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Chuanzhao Zhang (ORCID: https://orcid.org/0000-0002-9782-6970)
- Zhenchong Li (ORCID: https://orcid.org/0000-0001-5266-5977)
- Shiye Ruan
- Hexian Shi
- Shanzhou Huang
- Zhongyan Zhang
- Jike Fang
- Jiayu Yang
- Qian Yan
- Baohua Hou
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Boxing People's Hospital (CN)
- Xiyuan Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- University Medical Centre Mannheim (DE)
- Southern Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-10-07
- DOI
- https://doi.org/10.1097/js9.0000000000003596
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.00