Multi‐Omics Revealed the Effects of Intrauterine Hyperglycemia Exposure on the Development of Skeletal Muscle in Offspring
IUHG disrupts skeletal muscle development and metabolic function in offspring through structural, transcriptional and epigenetic alterations. Postnatal exercise partially reversed these impairments, highlighting its potential as a non-pharmacological intervention. These findings provide new insights into the developmental origins of skeletal muscle dysfunction in GDM-exposed offspring and underscore the importance of early prevention strategies.
Authors
- Rui Liu (ORCID: https://orcid.org/0000-0002-2014-180X)
- Yan Xu (ORCID: https://orcid.org/0000-0001-5681-0908)
- JianZhong Sheng
- Jiaying Mo
- Junsen She
- Hefeng Huang
- Yishang Yan
- Xinyuan Li
Institutions
- Zhejiang International Studies University (CN)
- Ministry of Education (TH)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1002/jcsm.70177
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00