Dose-dependent neurotoxic chemotherapy and corneal nerve morphological changes

Average nerve fibre length loss may have clinical utility as an early marker of CIPN progression. Imaging a wider area of the sub-basal corneal nerve plexus including the inferior whorl region may be more beneficial for monitoring early neuropathic changes.

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Publication Details

Journal
Clinical and Experimental Optometry
Published
2026-01-22
DOI
https://doi.org/10.1080/08164622.2025.2606161
Primary Topic
Intraoperative Neuromonitoring and Anesthetic Effects
Type
article
Field-Weighted Citation Impact
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article

Dose-dependent neurotoxic chemotherapy and corneal nerve morphological changes

Maria Markoulli, Michael Leonard Friedlander, Dimitra Makrynioti, Craig Lewis et al.
Clinical and Experimental Optometry
Intraoperative Neuromonitoring and Anesthetic Effects
article

Dose-dependent neurotoxic chemotherapy and corneal nerve morphological changes

Maria Markoulli, Michael Leonard Friedlander, Dimitra Makrynioti, Craig Lewis, Susanna B. Park, E. Hovey, Thomas Naduvilath, Jeremy Chung Bo Chiang, Kimberley Au, D. Goldstein, Siobhan O'Neill, Terry Trinh, Sultan Alotaibi, Arun V Krishnan
article en

Abstract

Average nerve fibre length loss may have clinical utility as an early marker of CIPN progression. Imaging a wider area of the sub-basal corneal nerve plexus including the inferior whorl region may be more beneficial for monitoring early neuropathic changes.

Clinical and Experimental Optometry
The University of Sydney (AU), University of Patras (GR), King Saud University (SA), UNSW Sydney (AU)
Good health and well-being
Openalex Percentile: Top 80%
Intraoperative Neuromonitoring and Anesthetic Effects
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