Relationship of Plasma <i>p</i> ‐tau217 and Mild Behavioral Impairment in Elderly Individuals Without Dementia
These findings suggest that p-tau217 could play a role in MBI, particularly in the impulse dyscontrol and emotion dysregulation domains, neuropsychiatric symptoms which have been previously linked to Alzheimer's disease. However, overall cognitive status emerged as the strongest predictor of these behavioral symptoms in older adults. Further research is warranted to clarify how p-tau217 levels and cognitive decline interact to influence the risk and progression of MBI.
Authors
- Nesrine Rahmouni
- Wan Lu Jia
- Elise J. Levinoff
- Tevy Chan (ORCID: https://orcid.org/0009-0001-9134-5949)
- José A. Morais (ORCID: https://orcid.org/0000-0001-9366-6626)
- J. K. M. ller Stevenson
- Anna Marier
- Lydia Trudel (ORCID: https://orcid.org/0009-0002-5593-7717)
- Stuart William Mitchell
- Arthur Macedo
- Etienne Aumont
- Pedro Rosa-Neto
- Joseph Therriault
- Seyyed Ali Hosseini
- Gleb Bezgin
- Wyllians Vendramini Borelli
- Brandon J Hall
- Ana Paula Bernardes Real
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Universidade Federal do Rio Grande do Sul (BR)
- Université du Québec à Montréal (CA)
- McGill University Health Centre (CA)
- Instituto do Cérebro (BR)
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107716
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00