IL-33 Alleviates Sepsis-Induced Liver Injury by Regulating theNF-κB/BCL-2 Pathway
Our results suggest that the pharmacologically targeted IL-33/ST2-NF-κB-BCL-2 pathway decreases sepsis-induced hepatocyte apoptosis. These findings indicate that IL-33-based treatments may be feasible for treating SILI and that this axis coordinates cytoprotection by concurrently controlling inflammatory signals and apoptotic processes.
Authors
- Liuzi Wei
- Shilai Li
- Guojun Zheng (ORCID: https://orcid.org/0009-0000-8186-7359)
- Liming Shang
- Cailu Chen
- Jiarui Zhang
- Zexin Li
- Shaolei Wu
- Zhidong Su
Institutions
- Guangxi Medical University (CN)
- Beihai People's Hospital (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2026-01-13
- DOI
- https://doi.org/10.2174/0109298673423384251128081056
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00