Integrative multi-omics analyses identify key genes and elucidate bidirectional regulatory mechanisms in thyroid dysfunction

Through multi-omics integration, this study identifies PDE8B as a central gene associated with thyroid dysfunction, characterized by tissue-specific colocalization, and elucidates its critical roles in signaling pathways, comorbidity associations, and drug targeting. These findings provide insights into the bidirectional regulatory mechanisms of hyperthyroidism and hypothyroidism and a theoretical basis for developing phosphodiesterase family-based precision therapies. It should be noted that all samples in this study are of European ancestry, and the generalizability of the results in other ethnic groups remains to be verified.