Evaluation of cytochrome P450 (CYP) induction using RT‐qPCR in exosomes isolated from plasma samples: Method development and qualification
We present a robust workflow for detecting several CYP mRNAs in plasma-derived exosomes and demonstrate proof-of-concept induction in preclinical and clinical samples. However, larger prospective studies are required to validate clinical utility.
Authors
- Scott Fauty
- Daniel S. Spellman (ORCID: https://orcid.org/0000-0001-7155-2329)
- Zhizhang Yin
- Brahim Achour (ORCID: https://orcid.org/0000-0002-2595-5626)
- Weixun Wang (ORCID: https://orcid.org/0000-0002-2727-8948)
- Christopher R. Gibson (ORCID: https://orcid.org/0000-0002-1719-8629)
- Shengjie Xu
- Nanyan Rena Zhang
- Xiaoyan Chu
Institutions
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- University of Rhode Island (US)
- United States Military Academy (US)
- Bioanalytica (Switzerland) (CH)
- Incyte (United States) (US)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1002/bcp.70453
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00