Immune Imbalance Drives Keloid Pathogenesis: Emerging Targets for Precision Immunotherapy
The absence of validated keloid models and large-scale trials limits translation. Future research must integrate immune profiling, biomarker validation, and mechanistic modeling to enable personalized interventions. Immune dysregulation is not merely an epiphenomenon-it is the Achilles' heel of keloids, offering unprecedented opportunities for targeted therapy and recurrence prevention.
Authors
- Shujun Wan (ORCID: https://orcid.org/0000-0002-0552-5303)
- Yuanyuan Duan
- Min Zhang
- Qilei Chen
- Jing Yan
Institutions
- Wannan Medical College (CN)
- Nanjing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese Academy of Medical Sciences Dermatology Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Jiangning Hospital (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- Advances in Wound Care
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1177/21621918261417702
- Primary Topic
- Dermatologic Treatments and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00