Suppressing Endothelial–Mesenchymal Transition Through the Histone Deacetylase 1/GATA Binding Protein 4 Pathway: The Mechanism of Protocatechuic Acid Against Myocardial Fibrosis Revealed by an Integrated Study
Protocatechuic acid alleviates inflammation and EndMT by inhibiting the HDAC1/GATA4 signaling pathway, thereby preserving cardiac function and retarding the progression of myocardial fibrosis. These findings provide a theoretical and experimental foundation for the potential application of protocatechuic acid in treating cardiovascular diseases.
Authors
- Guanfeng Xu
- Haitong Wan
- Chengsi Jin
- Chongyu Shao
Institutions
- Zhejiang Chinese Medical University (CN)
- China Academy of Chinese Medical Sciences (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Biology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3390/biology15020206
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zhejiang Chinese Medical University