Integrated Network Pharmacology, LC-MS/MS, and Experimental Validation of Fangji-astragalus in Hyperlipidemia
In summary, our study confirms the therapeutic effects of FJ-HQ on hyperlipidemia and identifies calycosin as a crucial component. Furthermore, we have experimentally validated the influence of FJ-HQ on the PI3K/AKT/mTOR signaling pathway. These findings highlight the potential of FJ-HQ as an effective lipid-lowering agent and provide preclinical evidence for future treatments of hyperlipidemia.
Authors
- Mi Zhang (ORCID: https://orcid.org/0000-0001-6410-6128)
- Chunlei Fan
- Wangqin Wu
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Current Computer - Aided Drug Design
- Published
- 2026-01-12
- DOI
- https://doi.org/10.2174/0115734099415670251126111224
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00