Neurofilament light chain as a surrogate candidate for disease activity in multiple sclerosis (LUMINOUS)—A meta-regression of randomized controlled trials
In MS, treatment effects on s/pNfL are moderately associated with therapeutic effects on ARR, MRI new/enlarging T2 lesions, and CDW, whereas no consistent association was observed with PBVC.
Authors
- Friederike Held (ORCID: https://orcid.org/0009-0008-1190-9435)
- Kimberly Koerbel (ORCID: https://orcid.org/0000-0002-7081-3096)
- Robert Barket (ORCID: https://orcid.org/0000-0001-6909-6109)
- Poljanka Johnson (ORCID: https://orcid.org/0000-0003-4153-428X)
- Frederik Bartels (ORCID: https://orcid.org/0000-0003-3523-4520)
- Valeria Pozzilli (ORCID: https://orcid.org/0000-0002-0556-0176)
- Roxanne Pretzsch (ORCID: https://orcid.org/0009-0001-4129-1276)
- Mafalda Delgado Soares
- I. Schiavetti
- Alessandro Cagol
- Elena Barbuti
- Albulena Bajrami
- Sahla El Mahdaoui
- Bernhard Hemmer
- Christian Cordano
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Goethe University Frankfurt (DE)
- University of British Columbia (CA)
- Innsbruck Medical University (AT)
- Università Campus Bio-Medico (IT)
- University Hospital of Basel (CH)
- Agostino Gemelli University Polyclinic (IT)
- Copenhagen University Hospital (DK)
- Ospedale Santa Chiara (IT)
- Hospital de São José (PT)
- Provincia Autonoma di Trento (IT)
- Munich Cluster for Systems Neurology (DE)
- Azienda Ospedaliera Sant'Andrea (IT)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Danish Multiple Sclerosis Center (DK)
- Ospedale Policlinico San Martino (IT)
- Servizio Sanitario Nazionale (IT)
- Technical University of Munich (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Multiple Sclerosis Journal
- Published
- 2026-01-23
- DOI
- https://doi.org/10.1177/13524585251407973
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 36.00