Research Advances in Therapeutic Strategies and Drug Delivery Systems for Pathological Scars

Pathological scars are fibrotic lesions that result from aberrant wound healing following tissue injury, such as burns. They are frequently associated with disfigurement and dysfunction, thereby severely impairing the quality of life of affected patients. Current clinical treatments, including surgery, laser therapy, and corticosteroid injections, are often characterized by limited efficacy, high recurrence rates, and undesirable side effects, including skin atrophy. Furthermore, the dense structure and excessive extracellular matrix (ECM) deposition in scar tissue present a significant barrier to effective drug penetration, thereby further limiting therapeutic efficacy. In recent years, biomaterial-based drug delivery systems, which integrate sustained drug release with minimally invasive transdermal technologies, have emerged as a promising strategy to overcome the limitations of traditional therapies. This review systematically outlines the pathogenesis and molecular mechanisms of pathological scars, summarizes established and emerging treatments, and highlights the application strategies and future prospects of novel biomaterial-based drug delivery systems for managing this condition.