A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity
Genetic analysis using modern and evolutionary datasets identifies a persistent and highly prevalent lupus-associated coding haplotype in <i>IRF7</i> at 11p15 The <i>IRF7</i> lupus risk haplotype increases IFN-α production by monocytes and airway epithelial cells The <i>IRF7</i> lupus risk haplotype increases IRF7 DNA binding strength and alters DNA sequence specificity A homologous lupus risk variant in mouse <i>Irf7</i> enhances control of vesicular stomatitis virus and exacerbates autoantibody production.
Authors
- Emily R. Miraldi (ORCID: https://orcid.org/0000-0002-0232-3116)
- M Petri
- B. Glenn Stuart
- Yasine Keddari
- Yuriy Baglaenko (ORCID: https://orcid.org/0000-0002-9020-6824)
- Lee Edsall (ORCID: https://orcid.org/0000-0002-0326-2829)
- M E Comeau
- J. Guthridge
- Kathryn A. Creighton
- Deborah Cunninghame Graham
- Leah C. Kottyan (ORCID: https://orcid.org/0000-0003-3979-2220)
- H C Ainsworth
- H. Hesse
- G Gilkeson
- Maryam Dashtiahangar
- Timothy J. Vyse (ORCID: https://orcid.org/0000-0003-1123-1464)
- Samuel J. Virolainen (ORCID: https://orcid.org/0000-0001-5331-7384)
- Swapan K. Nath (ORCID: https://orcid.org/0000-0001-6013-9328)
- J. Kelly
- Patrick M. Gaffney (ORCID: https://orcid.org/0000-0002-1580-869X)
- Lucinda P. Lawson (ORCID: https://orcid.org/0000-0003-3939-7829)
- K. Sivils
- Arthur T. Lynch
- Lois Parks (ORCID: https://orcid.org/0000-0001-5689-7492)
- Marta Alarcon-Riquelmé
- Trevor Siggers (ORCID: https://orcid.org/0000-0002-8039-7639)
- L. González Vila
- Olivia E. Gittens
- S Bae
- Harsha Seelamneni
- Betty P. Tsao (ORCID: https://orcid.org/0000-0001-7938-5975)
- Andrew VonHandorf (ORCID: https://orcid.org/0000-0003-2495-2324)
- Brad R. Rosenberg (ORCID: https://orcid.org/0000-0002-5885-1276)
- Ellen F Javier
- Sydney H Jones (ORCID: https://orcid.org/0009-0005-2674-4029)
- Arame A. Diouf
- Graciela S. Alarcón
- Shen Nan
- Xiaoting Chen (ORCID: https://orcid.org/0000-0002-5606-3081)
- Carmy Forney (ORCID: https://orcid.org/0000-0001-6418-5794)
- Katelyn Dunn
- Akshata Rudrapatna
- Omer Donmez
- Stephen N. Waggoner
- John D. Reveille
- Miranda C. Marion
- Cailing Yin
- Matthew Hass
- Rosalind Ramsey-Goldman
- John B. Harley
- Carl D. Langefeld
- Lindsey A. Criswell
- Elizabeth E. Brown
- Sreeja Parameswaran
- Graciela S. Alarcon
- Britney Ampadu
- Diane L. Kamen
- Oded Danzinger
- Kenneth M. Kaufman
- Judith A. James
- Barry I. Freedman
- R. Hal Scofield
- Matthew T. Weirauch
Institutions
- Rutgers, The State University of New Jersey (US)
- Boston University (US)
- Northwestern University (US)
- Cincinnati Children's Hospital Medical Center (US)
- Guy's Hospital (GB)
- Janssen (Belgium) (BE)
- Johns Hopkins University (US)
- Medical University of South Carolina (US)
- University of Puerto Rico, Medical Sciences Campus (PR)
- Shanghai Jiao Tong University (CN)
- Oklahoma City University (US)
- Johns Hopkins Medicine (US)
- Veterans Health Administration (US)
- Renji Hospital (CN)
- Harvard University Press (US)
- Karolinska Institutet (SE)
- Oklahoma Medical Research Foundation (US)
- University of Alabama at Birmingham (US)
- National Human Genome Research Institute (US)
- Oklahoma City VA Medical Center (US)
- Johnson & Johnson (Sweden) (SE)
- Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (ES)
- Hanyang University Seoul Hospital (KR)
- Cincinnati VA Medical Center (US)
- Department of Veterans Affairs (AU)
- King's College Hospital (GB)
- The University of Texas Health Science Center (US)
- Hanyang University (KR)
- Wake Forest University (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Cincinnati (US)
- University of Oklahoma (US)
- University of Cincinnati Medical Center (US)
- University of Colorado Denver (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-22
- DOI
- https://doi.org/10.64898/2026.01.21.26344474
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00