Neurodevelopmental effects of severe hypoglycemia in children with type 1 diabetes: a systematic review

This review indicates that severe hypoglycemia in children with Type 1 diabetes mellitus (T1DM) may lead to subtle but significant long-term impacts on neurocognitive abilities and brain structure. The strongest effects are observed in cases of recurrent or early-onset severe hypoglycemia. To mitigate risks, it is crucial to implement preventive measures such as educating caregivers, utilizing real-time glucose monitoring, and identifying hypoglycemia unawareness early. Future studies should focus on large-scale longitudinal and neuroimaging research to explore causal relationships and discover protective factors.