Investigating predictors of pain events during trials of knee osteoarthritis: A post-hoc analysis of two phase III trials

The study identifies female sex and certain medical histories as significant predictors of PEs in knee OA patients. A higher BMI was associated with lower odds of reporting PEs but for those who reported PEs, higher BMI was associated with more severe PEs. These results should be interpreted with caution due to methodological limitations, however the findings indicate risk factors for pain events and suggest further research into these associations.